Research Stories

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  • Professor Wonyoung Lee’s group develops the world’s best-performing proton conducting fuel cell Mechanical Engineering
    Prof. LEE, WON YOUNG
    Post-doc researcher Mingi Choi

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    Professor Wonyoung Lee’s group develops the world’s best-performing proton conducting fuel cell
  • [Past Contents]

    Developement of artificial intelligence semiconductor: optoelectronic synaptic device Electronic and Electrical Engineering
    Prof. PARK, JIN HONG
    Dr. Seunghwan Seo & Dr. Je-Jun Lee

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    Developement of artificial intelligence semiconductor: optoelectronic synaptic device

Research News

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  • 의학과 이창우 교수 연구팀,  간암 발병의 새로운 원인 규명 및 치료표적 제시
    A research team led by Professor Chang Woo Lee identified a new cause of liver cancer and presented treatment targets

    A research team led by Professor Chang Woo Lee from Department of Medicine, Identified a new cause of liver cancer and presented treatment targets - Identified a new regulatory mechanism that develops steatohepatitis into liver cancer Sungkyunkan University (President Dong Ryeol Shin) announces that a research team led by Professor Chang Woo Lee (Molecular Tumor Immunology Laboratory, first author: Jun Seop Yoon) identified a new cause of liver cancer and presented treatment targets. The team identified the plasticity and malignant change of liver cancer caused by reverse differentiation of liver cells and revealed a new and important regulatory mechanism for develop a new regulatory mechanism that develops steatohepatitis into liver cancer. Liver cancer is the fifth most common cancer in Korea, ranking second in the cause of cancer death after lung cancer. The reason why the mortality rate of liver cancer is so high is that it is difficult to fundamentally treat liver cancer because the mechanism of early diagnosis and regulation that develops into liver cancer is not clearly identified. Currently, chemotherapy for liver cancer has a very low response rate and there is no special method other than liver resection or liver transplantation. In fact, in case of liver resection, the recurrence rate is also very high at 50-70% within 5 years. Studies have shown that if hepatitis persists, it is transformed into tumor initiating cells that can produce cancer through the process of reverse differentiation of differentiated liver cell. However, the mechanism of molecular regulation that reversely differentiates liver cell has not yet been clearly identified. The research team noted a sharp decrease in Ssu72 protein in the liver cancer. Additionally, it was confirmed that liver cell with hepatitis develops into liver cancer cell by reverse differentiation in Ssu72 gene-deficient mice. This reveals a new regulatory mechanism that rapidly increases the development of hepatitis to liver cancer by inducing reverse differentiation of liver cells in an inflammatory environment caused by continuous liver damage, and it is found to occur through the regulation of HNF4α’s activity, which is essential to the differentiation and function of liver cells. Professor Lee said, “The occurrence of liver cancer due to continuous liver damage is considered to be a key mechanism for regulating the reverse differentiation of liver cells by the Ssu 72 gene. It is a significant study that suggests a new concept of liver cancer and a new treatment target.” The result of this study has been published in Cell Death and Differentiation (SCI IF 15.881) in October. Apart from the research results described above, Prof. Lee published excellent research results that have identified a new molecular mechanism for regulating the function of Regulatory T cell, which is essential for autoimmune control, and a new pathogenesis mechanism for autoimmune diseases, as correspondence authors in Proceedings of the National Academy of Sciences USA (SCI IF 11.205) in September and Cellular and Molecular Immunology (SCI IF 11.530) in March, respectively.

    2021-10-13

  • 경제학과 김대한 학부생(지도교수 류두진), Q1 SSCI학술지 논문 게재
    Daehan Kim, an undergraduate student in economics (Academic adviser: Prof. Doo Jin Ryu) published a paper on Q1 SSCI jou

    Daehan Kim, an undergraduate student in economics (Academic adviser: Prof. Doo Jin Ryu) published a paper on Q1 SSCI journal A paper co-authored by Daehan Kim, an undergraduate student in economics, and his academic adviser, Professor Doo Jin Ryu, was published on Financial Innovation (Impact Factor=3.985), which is the Q1 (Top 19%) SSCI journal in Business/Finance field. Daehan Kim, is a third-term student of Prof. Ryu’s research credit system, and first wrote an academic paper through a research credit course offered by the Department of Economics. It is unprecedented that an undergraduate student to publish a paper as the first author in a top SSCI Journal in the field of finance. Unlike the field of science and engineering, it is very rare to publish a paper on SSCI Journal even for Ph.D. students. As cryptocurrency has become a useful tool for money laundering, financial authorities around the world are expanding the scope of anti-money laundering regulations from traditional financial institutions to cryptocurrency exchanges. In Korea, under the “Act on Reporting and Use of Specific Financial Transaction Information”, virtual asset operators or cryptocurrency exchanges, are required to register with the Financial Services Commission and report suspicious activities such as money laundering. The key point of this paper is to show that the exchange’s reporting behavior of suspicious activities may appear more than the optimal level through the economic theory model. ※ Title of Paper “Are suspicious activity reporting requirements for cryptocurrency exchanges effective?” Financial Innovation (SSCI), 2021, 7:78, Springer. URL: https://jfin-swufe.springeropen.com/articles/10.1186/s40854-021-00294-6

    2021-10-06

  • 성균관대학교
    Prof. Sungho Park's Team Designed Complex Au Nanorings with Interwined Triple Rings in a Single Entity

    A Research Team led by Professor Sungho Park Designed Complex Au Nanorings with Interwined Triple Rings in a Single Entity to Amplify the Efficacy of Near-field focusing in a Solution Phase - Expected to be used in various fields such as nano, optical, sensor, bio, etc. - Selected as a cover page for the JACS As global interest in sustainable energy increases, the importance of developing materials that can efficiently concentrates sunlight is increasing. Among them, plasmonic nanoparticles are essential materials for various application studies that require efficient conversion of light energy into electric energy or thermal energy, including applied research using light energy because they can amplify interaction with light. The research team led by Sungho Park, professor of chemistry at Sungkyunkwan University (first author: Sungjae Yoo) is actively working on developing nanoframe materials with maximized structural complexity to increase the physical and chemical properties of plasmonic nanoparticles. The team designed complex Au nanorings with interwined triple rings in a single entity to amplify the efficacy of near-field focusing in a solution phase for the first time. Using the newly developed chemical reactions, the researchers rationally designed the multiple step synthesis method to control the internal nanogap distance of the triple nanoring structure and refine the shape of the frame structure, and further integrate four nanoring structures of different sizes inside a single particle. The synthesized triple ring structure exhibited an enormously large enhancement factor (∼109) of Raman signals, which is more than 100 times compared to conventional plasmonic gold particles, while simultaneously showing high signal reproducibility and stability regardless of the direction of light incident in a single nanoparticle. This is an innovative material that presents a new paradigm in the field of plasmonic particles, recognized for its significant contribution to the commercialization of Raman optical analysis techniques. Professor Sungho Park said “This study presents a methodology for controlling and analyzing nanoparticles and is expected to be widely used in various field such as nano, optical, sensor, bio, etc. This work was supported by the National Research Foundation of Korea (NRF) and was selected as the cover page of the Journal of the American Chemistry Society (Impact Factor: 15.419) in the field of chemistry and published online on August 9 (Mon). ※ Title of paper : Au Nanorings with Intertwined Triple rings

    2021-08-31